Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells
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Paclitaxel Induces Apoptosis in AIDS-Related Kaposi's Sarcoma Cells
Paclitaxel is a microtubule stabilizing drug that causes dividing cells to arrest and then undergo apoptosis. It also has antiangiogenic activity because it alters cytoskeletal structure, affecting migration and invasion. Paclitaxel is an effective treatment for AIDS-related Kaposi's sarcoma (KS). KS is a tumor in which there is marked proliferation of endothelial cells in addition to the tumor...
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متن کاملPathogenesis of AIDS--related Kaposi's sarcoma.
The occurrence of Kaposi's sarcoma (KS) in patients with HIV infection is more than 7,000 times higher than in the non-HIV infected population. The reason for this association is unclear but may involve decreased immune surveillance as a result of the profound cellular immune deficiency caused by HIV, a sexually transmitted KS-inducing virus, whose KS-transforming capabilities may be enhanced b...
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ژورنال
عنوان ژورنال: Sarcoma
سال: 2000
ISSN: 1357-714X,1369-1643
DOI: 10.1155/s1357714x00000074